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Dr. Michelangelo Certo is a Senior Researcher in Immunometabolism and Inflammation at the Institute of Inflammation and Ageing, University of Birmingham. He investigates the interconnections between metabolic and inflammatory pathways and how systemic and local metabolic alterations in diseases with an inflammatory component lead to aberrant immune cell responses, which favour both the establishment and the propagation of inflammation. In particular, he focuses on unveiling how specific metabolites, including lactate and fatty acids, can surprisingly act as signalling molecules modulating many aspects the immune-inflammatory response.                                                                                                 >>

                                                                                             

Featured Publications

Trends in Endocrinology & Metabolism

Understanding lactate sensing and signalling >>

 

Nature Reviews Immunology

Lactate modulation of immune responses in inflammatory versus tumour microenvironments >>

 

Cell Metabolism

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4 + T Cell Metabolic Rewiring >>

 


Visualizing Science

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