Spatial transcriptomics elucidates localized immune responses in atherosclerotic coronary artery

Joana Campos, Jack L McMurray, Michelangelo Certo, Ketaki Hardikar, Chris Morse, Clare Corfield, Bettina M Weigand, Kun Yang, Mohsen Shoaran, Thomas D Otto, Desley Neil, Pasquale Maffia & Claudio Mauro  

EMBO Molecular Nedicine, 2025, Vol. 17 , no. 10, pp.2827-2846.

Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution

Michelangelo Certo, Elena Pontarini, Sebastian G. Gilbert, Ronny Schmidt, Jason D. Turner, Davide Lucchesi, Daria Apostolo, Giulia Cavallaro, Charlotte G. Smith, Serena Colafrancesco, Joana Campos, Saba Nayar, Christoph Schröder, Benjamin A. Fisher, Fabian Spill, Michele Bombardieri & Claudio Mauro 

Nature Metabolism, 2025, Vol. 7 , no. 8, pp.1663-1680.

Lactate: A key regulator of the immune response

Llibre A, Kucuk S, Gope A, Certo* M, Mauro* C.

Immunity, 2025, Vol. 58 , no. 3, pp. 535-554.

The sedoheptulose kinase CARKL controls T-cell cytokine outputs and migration by promoting metabolic reprogramming.

Certo M, Niven J, Haas R, Rudzinska P, Smith J, Cucchi D, Hombrebueno JR, Mauro C.

Discovery Immunology, 2024, Vol. 3 , no. 1, kyae016.

Immunometabolism in atherosclerosis: a new understanding of an old disease.

Certo M, Rahimzadeh M, Mauro C.

Trends in Biochemical Sciences, 2024, Vol. 49 , no. 9, pp. 791-803.

Fluorinated perhexiline derivative attenuates vascular proliferation in pulmonary arterial hypertension smooth muscle cells.

Griffiths K, Grand RJ, Horan I, Certo M, Keeler RC, Mauro C, Tseng CC, Greig I, Morrell NW, Zanda M, Frenneaux MP, Madhani M.

Vascular Pharmacology, 2024, Vol. 156 , no. 107399.

Repurposing SGLT2 inhibitors for autoimmune diseases? Yes, we may.

Certo M, Niven J, Mauro C.

Cell Chemical Biology, 2023, Vol. 30 ,no. 9, pp. 1009-1011.

Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets.

Wijesinghe SN, Badoume A, Nanus DE, Sharma-Oates A, Farah H, Certo M, Alnajjar F, Davis ET, Mauro C, Lindsay MA, Jones SW.

Clinical and translational medicine, 2023, Vol. 13, no. 4, p. e1232.

Understanding lactate sensing and signalling.

Certo M, Llibre A, Lee W, Mauro C.

Trends in Endocrinology and Metabolism, 2022, S1043-2760(22)00136-9.

Omega-3 polyunsaturated fatty acids reverse the impact of western diets on regulatory T cell responses through averting ceramide-mediated pathways.

Camacho-Muñoz D, Niven J, Kucuk S, Cucchi D, Certo M, Jones SW, Fischer DP, Mauro C, Nicolaou A.

Biochemical Pharmacology, 2022, Vol. 204, no. 5, p. 115211.

Differential Metabotypes in Synovial Fibroblasts and Synovial Fluid in Hip Osteoarthritis Patients Support Inflammatory Responses.

Farah H, Wijesinghe SN, Nicholson T, Alnajjar F, Certo M, Alghamdi A, Davis ET, Young SP, Mauro C, Jones SW.

International Journal of Molecular Sciences, 2022, Vol. 23, no. 6, p. 3266.

Understanding the role of host metabolites in the induction of immune senescence: Future strategies for keeping the ageing population healthy

Conway J, Certo M, Lord JM, Mauro C, Duggal NA.

British Journal of Pharmacology, 2021, doi: 10.1111/bph.15671..

Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis.

Garcia AM, Bishop E, Li D, Jeffery L, Garten A, Thakker A, Certo M, Mauro C, Tennant DA, Dimeloe S, Evelo CT, Coort SL, Hewison M.

The Journal of Steroid Biochemistry and Molecular Biology, 2021, doi: 10.1016/j.jsbmb.2021.105891.

Lactate modulation of immune responses in inflammatory versus tumour microenvironments.

Certo M, Tsai CH, Pucino V, Ho PC, Mauro C.

Nature Review Immunology, 2021, Vol. 21, no. 3, pp. 151-161.

Metabolic Checkpoints in Rheumatoid Arthritis.

Pucino V, Certo M, Varricchi G, Marone G, Ursini F, Rossi FW, De Paulis A, Mauro C, Raza K, Buckley CD.

Frontiers in Physiology, 2020, Vol. 11, p. 347.

Omega-3 polyunsaturated fatty acids impinge on CD4+ T cell motility and adipose tissue distribution via direct and lipid mediator-dependent effects.

Cucchi D, Camacho-Muñoz D, Certo M, Niven J, Smith J, Nicolaou A, Mauro C.

Cardiovascular Research, 2020, Vol. 116, no. 5, pp. 1006-1020.

Lactate: Fueling the fire starter.

Certo M, Marone G, de Paulis A, Mauro C, Pucino V.

Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2020, Vol. 12, no. 3, p. e1474.

Endothelial and T cell crosstalk: targeting metabolism as a therapeutic approach in chronic inflammation.

Certo M, Elkafrawy H, Pucino V, Cucchi D, Cheung KCP, Mauro C.

British Journal of Pharmacology, 2020, doi: 10.1111/bph.15002.

Fatty acids - from energy substrates to key regulators of cell survival, proliferation and effector function.

Cucchi D, Camacho-Muñoz D, Certo M, Pucino V, Nicolaou A, Mauro C.

Cell Stress, 2019, Vol. 4, no. 1, pp. 19-23.

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.

Certo M, Pucino V, Bulusu V, Cucchi D, Goldmann K, Pontarini E, Haas R, Smith J, Headland SE, Blighe K, Ruscica M, Humby F, Lewis MJ, Kamphorst JJ, Bombardieri M, Pitzalis C, Mauro C.

Cell Metabolism, 2019, Vol. 30, no. 6, pp. 1055-1074.e8.

Selective neuronal silencing using synthetic botulinum molecules alleviates chronic pain in mice.

Maiarù, M., C. Leese, M. Certo, I. Echeverria-Altuna, A.S. Mangione, J. Arsenault, B. Davletov and S.P. Hunt

Science Translational Medicine, 2018, Vol. 10, no. 450, p. eaar7384.

Neuroprotective properties of a macrolide antibiotic in a mouse model of middle cerebral artery occlusion: characterization of the immunomodulatory effects and validation of the efficacy of intravenous administration.

Amantea, D., M. Certo, F. Petrelli and G. Bagetta

Assay and Drug Development Technology, 2016, Vol. 14, no. 5, pp. 298-307.

Caspase-1-independent maturation of IL-1β in ischemic brain injury: is there a role for gelatinases?

Amantea, D., R. Russo, M. Certo, L. Rombolà, A. Adornetto, L.A. Morrone, M.T. Corasaniti and G. Bagetta

Mini Reviews in Medicinal Chemistry, 2016, Vol. 16, no. 9, pp. 729-737.

Azithromycin protects against ischemic stroke through M2-polarization of peripheral macrophages.

Amantea, D., M. Certo, F. Petrelli, C. Tassorelli, G. Micieli, M.T. Corasaniti, P. Puccetti, F. Fallarino, and G. Bagetta

Experimental Neurology, 2016, Vol. 275, no. 1, pp. 116-125.

Activation of RXR/PPARγ underlies neuroprotection by bexarotene in ischemic stroke.

Certo, M., Y. Endo, K. Ohta, S. Sakurada, D. Amantea, and G. Bagetta

Pharmacological Research, 2015, Vol. 102, pp. 298-307.

Drug repurposing and beyond: the fundamental role of pharmacology. 

Amantea, D., M. Certo, and G. Bagetta

Functional Neurology, 2015, Vol. 30, no. 1, 79-81.

Rational modulation of the innate immune system for neuroprotection in ischemic stroke.

Amantea, D., G. Micieli, C. Tassorelli, M.I. Cuartero, I. Ballesteros, M. Certo, M.A. Moro, I. Lizasoain, and G. Bagetta

Frontiers in Neuroscience, 2015, Vol. 9, p. 147.

Neurorotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia.

Greco, R., C. Tassorelli, S. Mangione, G. Levandis, M. Certo, G. Nappi, G. Bagetta, F. Blandini, and D. Amantea

European Journal of Pharmacology, 2014, Vol. 744, pp. 91-97. 

Early reperfusion injury is associated to MMP2 and IL-1β elevation in cortical neurons of rats subjected to middle cerebral artery occlusion.

Amantea, D., M. Certo, R. Russo, G. Bagetta, M.T. Corasaniti, and C. Tassorelli

Neuroscience, 2014, Vol. 277, pp. 755-763.

Understanding the multifaceted role of inflammatory mediators in ischemic stroke.

Amantea, D., C. Tassorelli, F. Petrelli, M. Certo, P. Bezzi, G. Micieli, M.T. Corasaniti, and G. BagettaCurrent Medicinal Chemistry, 2014, Vol. 21, no. 18, pp. 2098-2117.